RNA Splicing & ER
Gene co-expression module in CD8⁺ T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes: SNRPD2 (Sm D2, core spliceosomal snRNP), HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1, pre-mRNA processing/splicing), FKBP8 (ER-localized FK506-binding protein/chaperone), TMED2 (p24 family ER-Golgi trafficking), ARHGDIB (Rho-GDI β, cytoskeletal regulation in lymphocytes), PFN1 (profilin-1, actin polymerization; shared with M13 actin neighborhood), MIF (macrophage migration inhibitory factor, also expressed by T cells), TRAC (TCR alpha constant chain — T cell identity). UBE2D3 (ubiquitin conjugating enzyme) and PPP1R18 (phosphatase regulator) are housekeeping. Core coherence with uniform expression. The dominant theme is RNA processing/splicing (SNRPD2, HNRNPA1) combined with ER/protein processing (TMED2, FKBP8). Neighbor relationship with M13 explains the actin genes (PFN1, ARHGDIB).
Genes
ARHGDIB, FKBP8, HNRNPA1, MIF, PFN1, PPDPF, PPP1R18, SNRPD2, TMED2, TRAC, UBE2D3
Most correlated modules
- Actin Cytoskeleton · correlation 0.89
- Gut Tissue Residency · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.