PFN1 — Profilin 1

PFN1 belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PFN1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Actin Cytoskeleton Cytoskeletal	ACTB, ACTG1, ACTR3, ARPC1B, ARPC2, ARPC4, ARPC5, BRK1 +14 more	View in SCUBA
CD4⁺ T cells	Actin cytoskeleton Cytoskeletal	ACTB, ACTG1, ARPC2, ARPC3, CLIC1, COPE, ELOB, GAPDH +3 more	View in SCUBA
CD8⁺ T cells	RNA Splicing & ER RNA processing & translation	ARHGDIB, FKBP8, HNRNPA1, MIF, PPDPF, PPP1R18, SNRPD2, TMED2 +2 more	View in SCUBA
Endothelial	Mitochondrial OxPhos Mitochondrial & OxPhos	ARPC1B, ATP5MF, AURKAIP1, NDUFB2, NDUFS6, PARVB, POLR2E, SERF2 +3 more	View in SCUBA
Fibroblasts	Actin Cytoskeleton Cytoskeletal	ACTB, CAPZA2, CFL1, CMTM6, COX8A, KIF5B, MORF4L2, NDUFS5 +6 more	View in SCUBA
Gamma-delta T cells	Cytotoxic Effector Actin cytotoxicity	ARPC2, ARPC5, ATOX1, BRK1, CFL1, CLIC1, CORO1A, DBI +14 more
Glial cells	ER Translocon Activity Protein processing & ER	ARPC2, CALR, EDF1, MRPL52, MYL6, NDUFA1, OST4, PPIB +3 more	View in SCUBA
Goblet cells	Mitochondrial Biogenesis Mitochondrial & OxPhos	ARPC5L, CALM1, EIF5A, LSM7, MRPL17, MRPL20, MRPL41, PRELID1 +4 more	View in SCUBA
Hematopoietic progenitor cells	MHC-I Antigen Presentation Myeloid development	ACTB, B2M, CALM2, CAPG, CYBA, EVI2A, EVI2B, FUT7 +10 more
Innate lymphoid cells	Actin Cytoskeleton Dynamics Cytoskeleton & motility	ACTB, ACTG1, ACTR3, ANAPC11, AP2S1, ARPC5, CALM3, CAPZB +11 more	View in SCUBA
Lymphatic endothelial	Actomyosin Cytoskeleton Cytoskeletal	BRI3, CD63, CFL1, CHCHD2, COX4I1, EDF1, GABARAPL2, HINT1 +8 more	View in SCUBA
Macrophages	Protein Homeostasis Mixed Housekeeping	ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 more	View in SCUBA
Mucosal-associated invariant T cell	Cytotoxic Lymphocyte Program cytotoxicity	ANXA11, CDKN2D, CYB5A, EMP3, ETHE1, FLT3LG, GLIPR2, LDHB +9 more
Natural Killer cells	Actin Cytoskeleton Remodeling Cytoskeleton & motility	ANXA6, ARPC1B, ARPC4, BAX, CAPNS1, CAPZB, GNAI2, IL2RG +7 more	View in SCUBA
Neutrophils	Actin Cytoskeleton Dynamics Cytoskeletal	ACTB, ACTG1, ARPC5, CFL1, CORO1A, ITGB2, MYL6, RGL4 +6 more
Smooth muscle cells	Respiratory Chain Subunits Mitochondrial & OxPhos	C19orf53, COX6A1, COX7B, MZT2B, NDUFB1, SNRPD2, SNX3, UBXN1 +2 more	View in SCUBA

About the gene

Chromosome	17: 4945652-4949061
Predicted location	Intracellular
Essential gene	Yes
Protein class	Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	Actin-binding

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.