Actin Cytoskeleton
Gene co-expression module in CD8⁺ T cells
| Category | Cytoskeletal |
|---|---|
| Genes | 19 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
The module is dominated by actin cytoskeleton regulators: ARPC1B and ARPC4 (Arp2/3 complex subunits), CAPZB (actin capping protein), CFL1 (cofilin-1, actin dynamics), CORO1A (coronin, actin organization), BRK1 (Arp2/3 activator HSPC300), ARF6 (actin/vesicle trafficking GTPase). ACTB (β-actin) is a core member. GAPDH and NDUFA13 add metabolic/housekeeping genes. FKBP1A (FK506-binding protein) and NEDD8 (neddylation) reflect protein regulation. Strong coherence and high pct positive (59%) support a constitutive cytoskeletal program. Neighbor M26 contains PFN1 (profilin, actin binding), reinforcing an actin-network neighborhood.
Genes
ACTB, ARF6, ARPC1B, ARPC4, BRK1, CAPZB, CFL1, CORO1A, FKBP1A, GAPDH, LSP1, MIEN1, NDUFA13, NEDD8, PPP1CA, RNF167, SERF2, TBCB, TRAPPC1
Most correlated modules
- Actin Cytoskeleton Dynamics · correlation 0.92
- ER-Golgi Trafficking · correlation 0.90
- Mitochondrial ETC/OxPhos · correlation 0.90
- Gut Tissue Residency · correlation 0.90
- RNA Splicing & ER · correlation 0.89
- IFN-gamma Stress Response · correlation 0.88
- Stress-ISG Response · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.