Gut Tissue Residency
Gene co-expression module in CD8⁺ T cells
| Category | Gut residence |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include CD3D (TCR complex), ID2 (transcription factor promoting tissue residency in CD8 T cells), RGS1 (regulator of G-protein signaling, marker of tissue-resident T cells in CRC), CXCR6-associated RHOC (Rho GTPase driving migration), S100A4 and S100A6 (calcium-binding proteins promoting motility), LGALS1 (galectin-1, immunosuppressive ligand/migration), VAMP8 (vesicle fusion/degranulation-associated), ALOX5AP (leukotriene biosynthesis), and CD7. RGS1 is a particularly strong gut tissue-residency marker. The combination of residency (ID2, RGS1), migration (RHOC, S100A4/A6, LGALS1), and T cell identity markers defines a gut tissue-resident CD8 T cell program.
Genes
ALOX5AP, C4orf3, CAPN2, CD164, CD3D, CD7, CD99, CLIC3, ID2, LGALS1, MAP4K1, NUCB1, RGS1, RHOC, S100A4, S100A6, SH3BGRL3, VAMP8
Most correlated modules
- Actin Cytoskeleton · correlation 0.90
- Stress-ISG Response · correlation 0.87
- Terminal Exhaustion · correlation 0.81
- Cytotoxic Effector · correlation 0.77
- RNA Splicing & ER · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.