Septin Cytoskeleton
Gene co-expression module in Innate lymphoid cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 27 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 27 genes have a known function matching the annotation |
Why this annotation
SEPTIN1, SEPTIN2, and SEPTIN9 are the dominant hub genes — septins are GTP-binding cytoskeletal proteins that form filaments and rings, regulating cell division, membrane organization, and cytokinesis. Their co-expression with NHERF1 (scaffold for cytoskeletal anchoring), GET3 (tail-anchored protein insertion), and ATP6V0C (vacuolar ATPase, membrane trafficking) suggests a cytoskeletal organization program. PSMB10 (immunoproteasome beta subunit) and IL10RB are peripheral. The significant negative delta_inflammation suggests this program is suppressed during gut inflammation.
Genes
ATP6V0C, C17orf49, CIAO2A, COX16, DARS1, DDOST, GET3, H2AC6, H3-3B, H4C3, HADHA, HMGN4, IGBP1, IL10RB, NDUFA7, NHERF1, PLAAT4, POLD4, POLR2J3, PSAP, PSMB10, PWWP3A, RBIS, SEPTIN1, SEPTIN2, SEPTIN9, TMEM35B
Most correlated modules
- Mitochondrial Organization · correlation 0.97
- NK Activating Receptors · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.