NK Activating Receptors
Gene co-expression module in Innate lymphoid cells
| Category | Cytotoxicity |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes NCR2 (NKp44) and KLRK1 (NKG2D) are canonical NK cell activating receptors. FLT3LG is an NK-stimulating cytokine ligand. CRACDL is an NK-associated gene. LTA4H is involved in leukotriene biosynthesis relevant to NK effector function. Strong ILC1 enrichment (up to 17x for NCR2) confirms NK/ILC1 identity. Despite weak coherence, the NK receptor program is biologically coherent.
Genes
CAT, CRACDL, ELAPOR1, FLT3LG, KLRK1, KRTCAP2, LTA4H, MFSD10, MLLT3, NCR2, PDK3, RAPGEF6, RPP21, SHFL, SHISA5, TMEM243
Most correlated modules
- Cellular Metabolic Maintenance · correlation 0.85
- Septin Cytoskeleton · correlation 0.83
- Interferon-Stimulated Genes · correlation 0.81
- Mitochondrial Organization · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.