IL10RB — Interleukin 10 receptor subunit beta
IL10RB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL10RB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Translation Mitochondrial & OxPhos | ABRACL, COX7A2L, DNAJC7, EGLN2, FAM217B, MPLKIP, MRPL36, MRPS10 +11 more | |
| Innate lymphoid cells | Septin Cytoskeleton Cytoskeleton & motility | ATP6V0C, C17orf49, CIAO2A, COX16, DARS1, DDOST, GET3, H2AC6 +18 more | View in SCUBA |
| Macrophages | Resident Mac Niche Tissue homeostasis | AGGF1, ALDH1A1, ARL5A, CD163L1, CD209, CHN2, CLEC4F, CLIC2 +22 more | View in SCUBA |
About the gene
| Synonyms | CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2 |
|---|---|
| Chromosome | 21: 33266367-33311420 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Antiviral defense |
Function
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.