Type I Interferon
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Inflammation |
|---|---|
| Genes | 18 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes RIGI (DDX58, dsRNA sensor), NMI (N-Myc interactor, IFN-induced), STAT2 (IFN signaling), TRIM5 (antiviral restriction), ZBP1 (Z-DNA/RNA sensor, innate immune), GBP1 (guanylate-binding protein, IFN-gamma induced), TNFSF10 (TRAIL, IFN-induced apoptosis ligand), TRIM25 (antiviral E3 ubiquitin ligase), SAMD9 (IFN-induced antiviral), PARP9 (ISG, antiviral), RTP4 (ISG), TRIM21 (IFN/antiviral), APOL2 (IFN-induced), ZNFX1 (antiviral RNA helicase) — this is a classic and tightly coherent Type I/II interferon-stimulated gene (ISG) module. Nearly every gene is a well-characterized ISG or innate antiviral effector. The module is strong coherence, uniform expression across MAIT subsets, consistent with an interferon-response state.
Genes
APOL2, CHMP5, COMMD8, FBXO6, GBP1, NMI, PARP9, RBCK1, RIGI, RTP4, SAMD9, STAT2, TNFSF10, TRIM21, TRIM25, TRIM5, ZBP1, ZNFX1
Most correlated modules
- Type I Interferon · correlation 0.83
- T cell Homeostasis · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.