SAMD9 — Sterile alpha motif domain containing 9
SAMD9 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SAMD9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | RNA & Chromatin Regulation RNA processing | ATRX, DCP2, DIP2A, HNRNPLL, KDM5B, NCOR1, OGDH, RIOK3 +7 more | View in SCUBA |
| CD8⁺ T cells | Interferon-stimulated Genes Inflammation | ADAR, GBP1, OAS2, PARP14, PARP9, RNF213, SAMD9L, SP110 +3 more | View in SCUBA |
| Endothelial | Type I Interferon Inflammation | CMPK2, HELZ2, IFI44, IFI44L, IFI6, IFIT1, IFIT2, IFIT3 +9 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Signaling Immune regulation | ABCF1, ABHD12, ACAP2, ADIPOR2, CBX6, ENPP4, FBXO9, GSAP +18 more | |
| Macrophages | Antiviral ISG Response Antiviral | ADAR, APOL6, ARID5A, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1 +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | APOL2, CHMP5, COMMD8, FBXO6, GBP1, NMI, PARP9, RBCK1 +9 more |
About the gene
| Synonyms | C7orf5, FLJ20073, KIAA2004 |
|---|---|
| Chromosome | 7: 93099513-93118023 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Immunity, Innate immunity |
Function
Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules. May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.