ZNFX1 — Zinc finger NFX1-type containing 1
ZNFX1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZNFX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Type I Interferon Response Inflammation | ADAR, DDX60, DTX3L, IFIH1, LAP3, OAS2, ODF3B, PARP9 +3 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACIN1, ASH1L, BDP1, BLTP1, CLTC, EPS15, EXOC2, FAM120B +24 more | |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | APOL2, CHMP5, COMMD8, FBXO6, GBP1, NMI, PARP9, RBCK1 +9 more |
About the gene
| Synonyms | FLJ11277, KIAA1404 |
|---|---|
| Chromosome | 20: 49237946-49278426 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | RNA-binding |
| Biological process | Antiviral defense, Immunity, Innate immunity |
Function
RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses. Acts as a double-stranded RNA (dsRNA) sensor that recognizes viral RNA and then interacts with MAVS to initiate the type I interferon response (By similarity). Also required for immunity against some bacteria, such as mycobacteria.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.