COMMD8 — COMM domain containing 8
COMMD8 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COMMD8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory activation Immune regulation | ATF7IP2, ATP10D, B3GALT2, GBP3, GFI1, GPR34, MAEA, MGAT1 +7 more | View in SCUBA |
| Gamma-delta T cells | Mitoribosome Small Subunit Mitochondrial & OxPhos | ACADM, C14orf119, CHCHD1, COA3, COA4, GALK1, GEMIN6, ISCA2 +24 more | |
| Innate lymphoid cells | Endosomal Trafficking Signaling Immune regulation | ARF1, CCDC85B, CKLF, FAM50A, GDE1, HAX1, IL27RA, LSM8 +16 more | View in SCUBA |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | APOL2, CHMP5, FBXO6, GBP1, NMI, PARP9, RBCK1, RIGI +9 more |
About the gene
| Synonyms | FLJ20502 |
|---|---|
| Chromosome | 4: 47450787-47463702 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin- RING E3 ubiquitin ligase (CRL) complexes. May down- regulate activation of NF-kappa-B.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.