STAT2 — Signal transducer and activator of transcription 2
STAT2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
STAT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ALPL, ARL4C, CD44, CHST15, CXCL6, DCBLD1, EVA1A, MAP3K5 +4 more | View in SCUBA |
| Gamma-delta T cells | Interferon Stimulated Genes Inflammation | AATF, ACSL5, ACTR10, AGL, DDX60, DTX3L, HCLS1, HIF1AN +14 more | |
| Macrophages | Antiviral ISG Response Antiviral | ADAR, APOL6, ARID5A, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1 +29 more | View in SCUBA |
| Monocytes | JAK-STAT IFN Signaling Antiviral | DDX60, GBP2, LAP3, PARP9, RNF213, SP110, STAT1, TNFSF10 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | APOL2, CHMP5, COMMD8, FBXO6, GBP1, NMI, PARP9, RBCK1 +9 more |
About the gene
| Synonyms | STAT113 |
|---|---|
| Chromosome | 12: 56341597-56360203 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Antiviral defense, Host-virus interaction, Transcription, Transcription regulation |
Function
Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.