TNFSF10 — TNF superfamily member 10

TNFSF10 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TNFSF10's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Th17 lineage Th17 fate	ADA, ARHGEF3, CD226, CD52, DENND3, EVL, IDH2, IL17RE +13 more	View in SCUBA
CD8⁺ T cells	IFN-gamma Response Inflammation	CASP3, GBP5, IFI16, IRF2, OPTN, SP100, SP140, WIPF1	View in SCUBA
Endothelial	MHC Class II Presentation Inflammation	CD74, CIITA, CST3, GSTK1, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DPA1 +7 more	View in SCUBA
Fibroblasts	Interferon Response Inflammatory	A4GALT, ABCA1, ABHD17C, BASP1, CCL7, CLEC2B, IFI16, IFI6 +5 more	View in SCUBA
Gamma-delta T cells	T Cell Survival T cell maturation	CASP1, CCDC107, CTU1, GEMIN7, GIMAP1, GIMAP2, GIMAP4, GIMAP5 +13 more
Goblet cells	Epithelial Junction Integrity migration & adhesion	ACTR2, ANXA2, CTNNA1, DSC2, GLUL, PERP, SERPINB1	View in SCUBA
Innate lymphoid cells	ILC1 Effector Activation activation	ADAM19, ARHGEF3, BATF, CD151, CDK4, FES, FURIN, HLA-F +16 more	View in SCUBA
Lymphatic endothelial	Endothelial Identity endothelial development	ARL6IP5, CLU, ICAM2, LY6E, NTS, NUCB1, PLAAT4, PROCR +2 more	View in SCUBA
Macrophages	Innate Antiviral Sensing Innate immunity	ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 more	View in SCUBA
Monocytes	JAK-STAT IFN Signaling Antiviral	DDX60, GBP2, LAP3, PARP9, RNF213, SP110, STAT1, STAT2 +1 more	View in SCUBA
Mucosal-associated invariant T cell	Type I Interferon Inflammation	APOL2, CHMP5, COMMD8, FBXO6, GBP1, NMI, PARP9, RBCK1 +9 more
Natural Killer cells	ILC1-like NK Subset Gut residency	CD2, IL12RB2, IL7R, KLRC1, LTB, SELL, SPTSSB, TMEM123 +2 more	View in SCUBA
Neutrophils	Innate DNA Sensing ISG Antiviral	AIM2, GIMAP4, IFI16, IRF2, RNF213, SHISA5, SP110, TMEM154 +1 more
Pericytes	MHC-II Antigen Presentation Inflammatory	CD74, CIITA, CYYR1, FLI1, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1 +4 more	View in SCUBA

About the gene

Synonyms	Apo-2L, CD253, TL2, TRAIL
Chromosome	3: 172505508-172523475
Predicted location	Intracellular, Membrane, Secreted
Essential gene	No
Protein class	Cancer-related genes, CD markers, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters
Molecular function	Cytokine
Biological process	Apoptosis

Function

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.