mRNA Splicing
Gene co-expression module in Natural Killer cells
| Category | RNA processing & translation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
The top hub genes are predominantly spliceosome and RNA processing factors: PNN (pinin, involved in mRNA splicing and retention), LUC7L3 (U1 snRNP splicing factor), DDX17 (DEAD-box RNA helicase involved in splicing), SNRPD3 (core spliceosomal snRNP protein), HNRNPH1 (heterogeneous nuclear ribonucleoprotein involved in splicing), RSRC2 (serine/arginine-rich splicing-related). GOLGB1 and FKBP2 are less directly related but may reflect secretory pathway activity. The module is significantly upregulated in both UC and CD inflammation, suggesting splicing machinery is activated in inflamed NK cells. This is a coherent RNA splicing module.
Genes
CHMP4A, DDX17, FAM107B, FKBP2, GOLGB1, HNRNPH1, LUC7L3, PNN, RSRC2, SNRPD3
Most correlated modules
- Cytokine Feedback Response · correlation 0.94
- Cellular Homeostasis · correlation 0.88
- Transcription Elongation Control · correlation 0.88
- NRF2 Stress Response · correlation 0.86
- Metabolic Activation · correlation 0.85
- NK Cell Activation · correlation 0.81
- TGF-beta Repression · correlation 0.80
- Heat Shock Response · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.