Metabolic Activation
Gene co-expression module in Natural Killer cells
| Category | Metabolism |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
LDHA (lactate dehydrogenase A, aerobic glycolysis), FABP5 (fatty acid binding protein, lipid metabolism), VDAC1 and SLC25A3 (mitochondrial membrane transport) indicate metabolic activity. NCL (nucleolin) and NOP56 are ribosome biogenesis factors. POMP is proteasome maturation protein. SERBP1 and SUB1 are transcriptional/RNA regulators. PTMA (prothymosin alpha) is associated with proliferation and chromatin remodeling. SNRPG is a spliceosomal component. The module is upregulated in CD inflammation. The dominant metabolic theme (LDHA, FABP5, VDAC1, SLC25A3) combined with ribosome biogenesis suggests a metabolically active, proliferating or activated NK cell state. LDHA-driven glycolysis is a hallmark of activated immune cells.
Genes
FABP5, LDHA, NCL, NOP56, POMP, PTMA, SERBP1, SLC25A3, SNRPG, SUB1, VDAC1
Most correlated modules
- hnRNP RNA Processing · correlation 0.87
- NRF2 Stress Response · correlation 0.86
- Cytokine Feedback Response · correlation 0.86
- mRNA Splicing · correlation 0.85
- S/G2M Cell Cycle · correlation 0.85
- NK Cell Activation · correlation 0.83
- TGF-beta Repression · correlation 0.83
- NK Activation Response · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.