Cellular Homeostasis
Gene co-expression module in Natural Killer cells
| Category | Metabolism |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub gene CD63 is a lysosomal/endosomal membrane protein involved in vesicle trafficking and NK cell degranulation. TMSB4X is a ubiquitous actin-sequestering peptide. OAZ1 regulates polyamine biosynthesis. ATP5F1E and ATP6V0E1 are mitochondrial/vacuolar ATPase subunits. DYNLRB1 is a dynein light chain involved in vesicle transport. APRT is a purine salvage enzyme. TRDC encodes the TCR delta constant region (present in NKT/gamma-delta T cells but also expressed in some NK cells). PSMA7 is a proteasome subunit. SSR4 is a translocon-associated protein. The module is a mixed housekeeping/metabolic program with vesicle trafficking and energy metabolism components. The uniform expression across subsets and moderate-to-strong coherence of most genes suggest a broadly active metabolic/housekeeping state. The presence of CD63 and DYNLRB1 hints at vesicle/lysosomal activity. Overall this resembles a general cellular homeostasis/metabolic module rather than a specific effector program.
Genes
APRT, ATP5F1E, ATP6V0E1, CD63, DYNLRB1, OAZ1, PSMA7, SSR4, TMSB4X, TRDC
Most correlated modules
- mRNA Splicing · correlation 0.88
- Cytokine Feedback Response · correlation 0.86
- Actin Cytoskeleton Remodeling · correlation 0.85
- NK Cytotoxic Signaling · correlation 0.80
- Metabolic Activation · correlation 0.79
- Translation Elongation · correlation 0.79
- NK Inflammatory Activation · correlation 0.78
- Oxidative Stress Response · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.