Heat Shock Response
Gene co-expression module in Natural Killer cells
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
The module is dominated by canonical heat shock proteins: HSPD1 (HSP60), HSPE1 (HSP10), HSP90AA1, HSP90AB1, HSPA8 (HSC70), HSPH1 (HSP105), AHSA1 (HSP90 co-chaperone), CHORDC1 (HSP90 co-chaperone), TCP1 (chaperonin CCT). CACYBP is a calcyclin-binding protein involved in protein ubiquitination. MRPL18 is a mitochondrial ribosomal protein. ANKRD37 is a hypoxia-inducible gene. The overwhelming majority of genes are cytosolic/mitochondrial chaperones. This is a tight, coherent heat shock/proteostasis module. Upregulated in UC remission. Neighbors M50 (inducible HSPs) and M36 (ER stress) confirm a proteotoxic stress neighborhood.
Genes
AHSA1, ANKRD37, CACYBP, CHORDC1, HSP90AA1, HSP90AB1, HSPA8, HSPD1, HSPE1, HSPH1, MRPL18, TCP1
Most correlated modules
- ER Stress Response · correlation 0.84
- Cytokine Feedback Response · correlation 0.83
- Transcription Elongation Control · correlation 0.80
- mRNA Splicing · correlation 0.79
- TGF-beta Repression · correlation 0.73
- NK Activation Response · correlation 0.73
- NRF2 Stress Response · correlation 0.72
- NF-κB Activation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.