Transcription Elongation Control
Gene co-expression module in Natural Killer cells
| Category | DNA regulation & transcription |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include NABP1 (single-stranded DNA binding, DNA damage response), RSRP1 (arginine/serine-rich RNA-binding), PPP1R10 (PP1 regulatory subunit involved in RNA processing and chromatin), YME1L1 (mitochondrial AAA protease, but here in context of RNA/transcription neighbors), MAT2A (methionine adenosyltransferase, one-carbon metabolism/methylation), FUS (RNA-binding protein, transcription/splicing), INTS6 (Integrator complex, RNA Pol II transcription termination), HEXIM1 (P-TEFb inhibitor, transcriptional elongation control), PCF11 (cleavage/polyadenylation factor, transcription termination), FAM53C and C6orf62 (less characterized but co-expressed with above). The dominant theme is transcriptional regulation and RNA processing — particularly transcription elongation control (HEXIM1, INTS6, PCF11) and RNA-binding (FUS, RSRP1). Upregulated in CD inflammation. No contamination signal; uniform expression across NK subsets. Neighbor modules M36 and M14 also involve RNA/protein processing, supporting a shared upstream stress/activation context.
Genes
C6orf62, FAM53C, FUS, HEXIM1, INTS6, MAT2A, NABP1, PCF11, PPP1R10, RSRP1, YME1L1
Most correlated modules
- Cytokine Feedback Response · correlation 0.89
- ER Stress Response · correlation 0.88
- mRNA Splicing · correlation 0.88
- TGF-beta Repression · correlation 0.87
- NF-κB Activation · correlation 0.84
- EGR2/3 NK Activation · correlation 0.84
- NRF2 Stress Response · correlation 0.84
- NK Activation Response · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.