Cytokine Feedback Response
Gene co-expression module in Natural Killer cells
| Category | Immune regulation |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
Hub gene PRPF4B is a pre-mRNA processing kinase; PAXX is a NHEJ DNA repair factor; N4BP2L2 is an RNA-binding protein; SOCS3 is a canonical JAK-STAT signaling suppressor upregulated in cytokine responses; VMP1 is involved in autophagy; DYNLL1 and PABPC1 are involved in RNA/protein regulation. The module is significantly upregulated in CD inflammation (delta=1.081, sig.), and SOCS3 is a well-known feedback inhibitor of cytokine signaling. The module appears to reflect a mixed stress/cytokine feedback response, with SOCS3 as the clearest functional anchor for inflammatory regulation. The heterogeneous gene composition suggests a moderate mixed program, but the CD inflammation signal and SOCS3 hub support a cytokine feedback/stress response label.
Genes
DYNLL1, LMO4, N4BP2L2, PABPC1, PAXX, PRPF4B, SOCS3, TPT1, VMP1
Most correlated modules
- mRNA Splicing · correlation 0.94
- Transcription Elongation Control · correlation 0.89
- NRF2 Stress Response · correlation 0.88
- Cellular Homeostasis · correlation 0.86
- Metabolic Activation · correlation 0.86
- NK Activation Response · correlation 0.85
- ER Stress Response · correlation 0.84
- TGF-beta Repression · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.