TGF-beta Repression
Gene co-expression module in Natural Killer cells
| Category | DNA regulation & transcription |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include SKIL (TGF-β/Smad repressor), ODC1 (polyamine biosynthesis), SKP1 (SCF E3 ligase component), UBE2D3 (ubiquitin conjugating enzyme), POLR2K and GTF2B (general transcription), and HBP1 (transcriptional repressor). The module combines TGF-β signaling repression (SKIL), ubiquitin-proteasome pathway (SKP1, UBE2D3), and basal transcription machinery. ODC1 links to polyamine metabolism and cell growth regulation. Upregulated significantly in CD inflammation. The combination suggests a general gene regulatory/proteostasis program rather than a single clean pathway.
Genes
BZW1, GTF2B, HBP1, ODC1, POLR2K, SKIL, SKP1, SPTY2D1, UBE2D3
Most correlated modules
- NF-κB Activation · correlation 0.93
- NK Activation Response · correlation 0.92
- NK Cell Activation · correlation 0.91
- EGR2/3 NK Activation · correlation 0.90
- Transcription Elongation Control · correlation 0.87
- NRF2 Stress Response · correlation 0.86
- ER Stress Response · correlation 0.85
- MAPK/AP-1 Signaling · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.