NK Cell Activation
Gene co-expression module in Natural Killer cells
| Category | activation |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub gene AKARIN1 (Akirin-1) is a nuclear protein involved in NF-κB-dependent inflammatory gene regulation and innate immune activation. SERP1 is an ER stress-related protein stabilizing membrane proteins during stress. GNL3 (nucleostemin) is a nucleolar GTPase involved in ribosome biogenesis and cell proliferation. PPP1CB is a serine/threonine phosphatase. DDX24 is an RNA helicase involved in ribosome assembly. ETF1 is a translation termination factor. EIF1AX is a translation initiation factor. AKAP9 is a scaffolding protein for kinase signaling. EZR (Ezrin) is a cytoskeletal linker involved in lymphocyte activation and migration. ALG13 is involved in N-glycosylation. YWHAZ (14-3-3 zeta) is a signaling scaffold. The module is significantly upregulated in CD inflammation. The combination of AKIRIN1 (NF-κB/innate immune), EZR (cytoskeletal activation), translation factors (ETF1, EIF1AX), and ribosome biogenesis (GNL3, DDX24) suggests a general cellular activation/translational upregulation program in response to inflammatory signals, consistent with NK cell activation in CD.
Genes
AKAP9, AKIRIN1, ALG13, DDX24, EIF1AX, ETF1, EZR, GNL3, PPP1CB, SERP1, YWHAZ
Most correlated modules
- TGF-beta Repression · correlation 0.91
- NK Activation Response · correlation 0.89
- NF-κB Activation · correlation 0.86
- NRF2 Stress Response · correlation 0.86
- MAPK/AP-1 Signaling · correlation 0.85
- Metabolic Activation · correlation 0.83
- mRNA Splicing · correlation 0.81
- NK Immune Checkpoint · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.