ILC1-like NK Subset
Gene co-expression module in Natural Killer cells
| Category | Gut residency |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes LTB (lymphotoxin-beta, lymphoid organogenesis/ILC), IL7R (CD127, ILC/T cell survival receptor), CD2 (T/NK cell adhesion), SPTSSB (sphingolipid synthesis), XCL2 and XCL1 (chemokines secreted by NK cells to recruit cDC1s), KLRC1 (NKG2A, inhibitory NK receptor), SELL (CD62L, lymph node homing), TNFSF10 (TRAIL, apoptosis-inducing ligand), TMEM123, and IL12RB2 (IL-12 receptor, NK/T cell activation). XCL1/XCL2 are hallmark NK cell chemokines. KLRC1 marks inhibitory/immature NK cells. IL7R and SELL together suggest a less mature, lymph-node-homing or ILC1-like NK subset. LTB and IL12RB2 support ILC1/NK cell identity. TNFSF10 (TRAIL) is a cytotoxic effector molecule. This module represents an ILC1-like or immature/circulating NK cell subset with chemokine secretion capacity, consistent with NK cells that recruit dendritic cells and respond to IL-12. The trend toward upregulation in CD inflammation (though not significant) is consistent with ILC1 expansion in IBD.
Genes
CD2, IL12RB2, IL7R, KLRC1, LTB, SELL, SPTSSB, TMEM123, TNFSF10, XCL1, XCL2
Most correlated modules
- Translation Elongation · correlation 0.60
- Mature NK Identity · correlation 0.57
- NK Cell Activation · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.