Translation Elongation
Gene co-expression module in Natural Killer cells
| Category | RNA processing & translation |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
EEF1A1, EEF1D, and EEF1B2 are all subunits of the eukaryotic translation elongation factor 1 complex, directly involved in mRNA translation. BTF3 is a nascent polypeptide-associated complex (NAC) beta subunit involved in co-translational processes. NACA is the NAC alpha subunit, also co-translational. PFDN5 is a prefoldin subunit involved in co-translational protein folding. RACK1 is a ribosome-associated scaffold protein. COMMD6 is a COMM domain protein. TOMM7 is a mitochondrial outer membrane translocase subunit. SEC11A is a signal peptidase complex subunit. EIF3E is a translation initiation factor subunit. NOP53 is a ribosome biogenesis factor. This module is dominated by translation elongation factors and co-translational chaperones, representing a tight translational machinery program. High mean expression (1.237) and high pct positive (79.7%) confirm broad housekeeping activity. The module is a neighbor to M34 (metabolic housekeeping), consistent with co-expression of general cellular activity programs.
Genes
BTF3, COMMD6, EEF1A1, EEF1B2, EEF1D, EIF3E, NACA, NOP53, PFDN5, RACK1, SEC11A, TOMM7
Most correlated modules
- Cellular Homeostasis · correlation 0.79
- NK Cytoskeletal Activation · correlation 0.63
- ILC1/NK Cytotoxic · correlation 0.63
- ILC1-like NK Subset · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.