IL12RB2 — Interleukin 12 receptor subunit beta 2
IL12RB2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL12RB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th1 IL12 response Immune regulation | ADCY3, AKIRIN2, CTNNA1, ETV7, HIVEP3, JAKMIP1, PTPN1, RFTN1 +2 more | View in SCUBA |
| Gamma-delta T cells | EOMES Effector Program T cell maturation | AGK, ANKZF1, ATG16L2, C6orf120, CARD8, CBX1, CDK5RAP3, CENPT +25 more | |
| Natural Killer cells | ILC1-like NK Subset Gut residency | CD2, IL7R, KLRC1, LTB, SELL, SPTSSB, TMEM123, TNFSF10 +2 more | View in SCUBA |
About the gene
| Chromosome | 1: 67307364-67398724 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.