TMEM123 — Transmembrane protein 123

TMEM123 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TMEM123's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Naive B-cell identity B cell maturation	ALOX5AP, CD79B, HLA-DOB, IRF8, NCF1, P2RX5, PLEKHF2, SEC62 +7 more	View in SCUBA
CD4⁺ T cells	Naive T cell T cell development	ABRAXAS1, ATP10A, BACH2, CASP10, FBLN5, GKAP1, HSBP1L1, MCUB +9 more	View in SCUBA
CD8⁺ T cells	Ribosome Biogenesis RNA processing & translation	BTF3, CCND3, EIF3H, EIF3L, ERP29, FBL, FXYD5, LDHB +8 more	View in SCUBA
Endothelial	Redox Stress Response Stress	APEX1, ATP5F1E, ATP5MC1, CDC42EP5, EIF4EBP1, EPS8L1, MAGED1, MCFD2 +7 more	View in SCUBA
Fibroblasts	Actin Cytoskeletal Organization Cytoskeletal	ACP1, AKR7A2, ARL3, CAPZB, DERL1, GDE1, LEPROTL1, LIMS1 +8 more	View in SCUBA
Gamma-delta T cells	TCR Signal Regulation TCR Signaling	ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, CXCR6 +22 more
Glial cells	Basement Membrane Adhesion ECM remodeling	ANTXR2, C2orf88, CHL1, DMD, GPC1, ITGAV, PRIMA1	View in SCUBA
Goblet cells	Ion Transport Homeostasis Housekeeping	APP, ATP1A1, CAPRIN1, CSDE1, EEF2, MAT2B, SLC12A2, VPS35	View in SCUBA
Lymphatic endothelial	Antigen Presentation IFN Inflammation	ADAR, GPRC5B, HLA-F, KTN1, PARP14, PTTG1IP, SCARB2, TAPBP +2 more	View in SCUBA
Monocytes	Glucocorticoid Transcription Inflammatory	HECTD1, JDP2, KLF13, KLF9, PER1, PIK3R1, ZBTB16	View in SCUBA
Mucosal-associated invariant T cell	Chemokine Receptor Migration migration & adhesion	CCR1, CCR2, CCR5, CD47, FAM78A, KRIT1, LUC7L3, MTG1 +6 more
Natural Killer cells	ILC1-like NK Subset Gut residency	CD2, IL12RB2, IL7R, KLRC1, LTB, SELL, SPTSSB, TNFSF10 +2 more	View in SCUBA
Pericytes	Immunoproteasome Induction Inflammatory	CANX, GRN, LY6E, NUCB1, PGK1, PSAP, PSMB8, PSMB9 +3 more	View in SCUBA
Smooth muscle cells	ER Secretory Trafficking Protein processing & ER	ARF4, DEGS1, GYPC, P4HB, PDIA6, SH3PXD2A, SSR3, TMED9	View in SCUBA

About the gene

Synonyms	KCT3, PORIMIN
Chromosome	11: 102396332-102470384
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Receptor

Function

Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.