SPTSSB — Serine palmitoyltransferase small subunit B
SPTSSB belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPTSSB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | γδT17 Effector Inflammation | AQP3, CCR6, CEBPD, COLQ, CTSA, CTSH, EDEM2, GCHFR +10 more | |
| Natural Killer cells | ILC1-like NK Subset Gut residency | CD2, IL12RB2, IL7R, KLRC1, LTB, SELL, TMEM123, TNFSF10 +2 more | View in SCUBA |
About the gene
| Synonyms | ADMP, C3orf57, ssSPTb |
|---|---|
| Chromosome | 3: 161344798-161372880 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Lipid metabolism, Sphingolipid metabolism |
Function
Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.