XCL1 — X-C motif chemokine ligand 1
XCL1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
XCL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Effector ISG Anti-viral | GOLGA7B, KIF5C, KIT, MAP2K6, MVB12B, NMUR1, PLCG1, PLOD3 +8 more | View in SCUBA |
| Gamma-delta T cells | XCL1/XCL2 Cytotoxic Activation cytotoxicity | BCL2A1, CCL3L3, CCL4L2, FASLG, ICAM1, IRF8, PLEKHO2, RILPL2 +6 more | |
| Innate lymphoid cells | NK Homing Circulating Homing & TEM | ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 more | View in SCUBA |
| Natural Killer cells | ILC1-like NK Subset Gut residency | CD2, IL12RB2, IL7R, KLRC1, LTB, SELL, SPTSSB, TMEM123 +2 more | View in SCUBA |
About the gene
| Synonyms | ATAC, LPTN, LTN, SCM-1, SCM-1a, SCYC1 |
|---|---|
| Chromosome | 1: 168576605-168582069 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Chemotaxis |
Function
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.