CD2 — CD2 molecule
CD2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR Complex Activation TCR/AP1/NFKb pathway | ABHD17A, ACTR3, C1GALT1, CD3D, CD3E, CD3G, CD81, CERK +14 more | View in SCUBA |
| CD8⁺ T cells | Terminal Exhaustion Exhaustion | ACP5, CARD16, CASP1, CD247, CD8A, CD8B, CHST12, CXCR6 +6 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ANKRD13D, ATP5ME, ATP5MJ, CAMTA1, CTDNEP1, DPP7, EIF3D, FBL +11 more | |
| Hematopoietic progenitor cells | ILC3/γδT Priming Lymphcyte development | C2CD4D, CCL1, CCR1, CD7, CHI3L2, FGR, GPR18, IL17RE +8 more | |
| Innate lymphoid cells | Innate Inflammatory Activation Inflammation | ARL6IP5, BST2, CD63, FTL, HMGB1, ITM2B, MGST3, MTDH +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cellular Housekeeping Housekeeping | ABI3, AP2M1, CD151, CKLF, DYNLL1, FDFT1, LRP10, NOP10 +7 more | |
| Natural Killer cells | ILC1-like NK Subset Gut residency | IL12RB2, IL7R, KLRC1, LTB, SELL, SPTSSB, TMEM123, TNFSF10 +2 more | View in SCUBA |
About the gene
| Synonyms | SRBC |
|---|---|
| Chromosome | 1: 116754430-116769229 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Cell adhesion |
Function
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.