Growth Arrest Stress
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
A small, heterogeneous module without a dominant pathway: WEE1 (G2/M checkpoint kinase, growth-arrest signaling), BOK (pro-apoptotic BCL2 family, ER-associated), CKAP4 (ER membrane/cytoskeleton-linking protein and antiproliferative receptor), CNKSR3 (SGK1-regulated scaffold), PTGS1 (COX-1 prostanoid synthesis), MXRA7, plus the poorly characterised C14orf132 and NBPF1. The combination of checkpoint, apoptotic and ER-stress-adjacent genes with only moderate membership for several members suggests a low-amplitude quiescence/growth-arrest stress state rather than a proliferative program; unlike its ECM-rich neighbors it carries no matrix signature, so the co-expression likely reflects a shared low-activity/quiescent cell state.
Genes
BOK, C14orf132, CKAP4, CNKSR3, MXRA7, NBPF1, PTGS1, WEE1
Most correlated modules
- SMC Contractile Signaling · correlation 0.86
- FOXF2 Mesenchymal Patterning · correlation 0.86
- Basement Membrane Matrix · correlation 0.82
- Collagen-Laminin Deposition · correlation 0.82
- Netrin Guidance Signaling · correlation 0.80
- Matrix-integrin interaction · correlation 0.79
- Integrin adhesion complex · correlation 0.77
- Lysosomal Glycoprotein Catabolism · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.