Matrix-integrin interaction
Gene co-expression module in Smooth muscle cells
| Category | ECM remodeling |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hubs LRP1 (matrix/ligand clearance receptor), FBN1 (fibrillin microfibrils), ITGAV and ITGA1 (collagen/RGD-matrix integrins), P4HA2 (collagen prolyl-4-hydroxylase, collagen maturation) and C1S (complement/ECM-associated protease) together define a matrix-receptor and collagen-processing program typical of a synthetic/matrix-producing smooth muscle state. VMP1 and EML1 are peripheral. Neighborhood context: sits next to adhesion modules (M47, M58) and the contractile module M19, consistent with the synthetic vs contractile SMC axis — this module is the ECM/matrix-interaction arm.
Genes
C1S, EML1, FBN1, ITGA1, ITGAV, LRP1, P4HA2, VMP1
Most correlated modules
- Collagen-Laminin Deposition · correlation 0.87
- Lysosomal Glycoprotein Catabolism · correlation 0.87
- Integrin adhesion complex · correlation 0.85
- Collagen Biosynthesis · correlation 0.85
- Notch-TGFbeta Signaling · correlation 0.84
- Basement Membrane Matrix · correlation 0.83
- FOXF2 Mesenchymal Patterning · correlation 0.82
- SMC focal adhesion · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.