Collagen-Laminin Deposition
Gene co-expression module in Smooth muscle cells
| Category | ECM remodeling |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Core hubs are fibrillar and network collagens (COL6A3, COL5A1, COL5A2) with basement-membrane laminins (LAMA4, LAMB1) and the focal-adhesion/actin-linkage pair PARVA–TES, plus RRBP1 (ribosome-binding ER protein supporting collagen translation) and guidance/adhesion molecules PCDH7, NEGR1, SEMA3C. This is a classic matrix-synthesis (synthetic/myofibroblast-like) SMC program coupling collagen output to integrin adhesion. It is functionally continuous with M24 (crosslinking/VCAN) and M25 (microfibril ECM) in the neighborhood.
Genes
COL5A1, COL5A2, COL6A3, LAMA4, LAMB1, NEGR1, PARVA, PCDH7, RAB32, RRBP1, SEMA3C, TES, WLS
Most correlated modules
- FOXF2 Mesenchymal Patterning · correlation 0.88
- Matrix-integrin interaction · correlation 0.87
- Collagen Biosynthesis · correlation 0.86
- Microfibril ECM Assembly · correlation 0.84
- Integrin adhesion complex · correlation 0.83
- Matrix Crosslinking Activation · correlation 0.83
- Growth Arrest Stress · correlation 0.82
- Basement Membrane Matrix · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.