Lysosomal Glycoprotein Catabolism
Gene co-expression module in Smooth muscle cells
| Category | Protein processing & ER |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Top genes are lysosomal/endolysosomal and secretory-pathway hydrolases and chaperones: GRN (progranulin, lysosomal), HEXB (beta-hexosaminidase), CPQ (lysosomal carboxypeptidase), FCGRT (endosomal FcRn), AKR7A2 (aldo-keto reductase detoxification), PPIC (ER peptidyl-prolyl isomerase), with matrix-associated CERCAM and LTBP1 and the fibroblast/pericyte marker MRGPRF. The signature reflects constitutive glycoprotein catabolism/secretory turnover in stromal cells rather than a stress or contamination program; it sits adjacent to the ECM-producing modules (M119, M24), consistent with coupled secretion and lysosomal recycling.
Genes
AKR7A2, CERCAM, CPQ, FCGRT, GRN, HEXB, LTBP1, MRGPRF, PPIC
Most correlated modules
- SMC focal adhesion · correlation 0.89
- Matrix-integrin interaction · correlation 0.87
- Basement Membrane Matrix · correlation 0.86
- Matrix Crosslinking Activation · correlation 0.84
- Notch-TGFbeta Signaling · correlation 0.83
- Integrin adhesion complex · correlation 0.82
- FOXF2 Mesenchymal Patterning · correlation 0.81
- Membrane Protein Turnover · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.