FOXF2 Mesenchymal Patterning
Gene co-expression module in Smooth muscle cells
| Category | Development |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes are gut mesenchymal developmental regulators and matrix modulators: FOXF2 (intestinal subepithelial mesenchyme TF), the FAT4–DCHS1 planar-cell-polarity cadherin pair, APCDD1 (Wnt inhibitor), MFAP5 (microfibril-associated), ADAMTS6 and PDGFC (growth factor/ECM processing), plus signaling receptors BDKRB2, P2RY14, KCNH2. This is a low-expressed but coherent mesenchymal patterning/positional-identity program rather than a contractile or inflammatory one. Its neighbors (M24 with FOXF1/NKX2-3, M25/M119 matrix modules) support a shared gut mesenchymal identity axis, with M30 being the transcription-factor/morphogen-signaling end of that axis.
Genes
ADAMTS6, APCDD1, BDKRB2, DCHS1, FAT4, FOXF2, KCNH2, MFAP5, P2RY14, PDGFC, PDIA5
Most correlated modules
- Microfibril ECM Assembly · correlation 0.93
- Collagen-Laminin Deposition · correlation 0.88
- Notch-TGFbeta Signaling · correlation 0.87
- Netrin Guidance Signaling · correlation 0.87
- Growth Arrest Stress · correlation 0.86
- Matrix Crosslinking Activation · correlation 0.85
- Neural Adhesion Program · correlation 0.84
- Matrix-integrin interaction · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.