Basement Membrane Matrix
Gene co-expression module in Smooth muscle cells
| Category | ECM remodeling |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
MXRA8 (matrix remodeling associated 8), VWA1 (von Willebrand factor A domain basement-membrane protein), EFEMP2/fibulin-4 (elastic fiber assembly) and RTN4/Nogo-B (vascular remodeling, ER-shaping in SMC) form a tight core of matrix/basement-membrane-associated genes; PRNP is also membrane/ECM-associated in mural cells. This is a matricellular/microfibril program, complementary to the proteolytic module M42 and the adhesion module M10 in the same neighborhood.
Genes
ADH5, C4orf48, EFEMP2, FBXL7, MLXIP, MXRA8, PRNP, RTN4, VWA1
Most correlated modules
- Lysosomal Glycoprotein Catabolism · correlation 0.86
- SMC Contractile Signaling · correlation 0.85
- Matrix-integrin interaction · correlation 0.83
- Growth Arrest Stress · correlation 0.82
- Pericellular Proteolysis · correlation 0.82
- Netrin Guidance Signaling · correlation 0.82
- Mesenchymal Adhesion Program · correlation 0.81
- Fibroblast-like Activation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.