Integrin adhesion complex
Gene co-expression module in Smooth muscle cells
| Category | Migration & adhesion |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
FERMT2 (kindlin-2, integrin activation), ITGA5 (fibronectin receptor), DST (dystonin, cytoskeletal cross-linker/hemidesmosomal plakin), RDX (radixin, ERM membrane–actin linker) and NPTN form an integrin-adhesion / cytoskeletal-anchoring program; PRKACB, NFIX, RAB23 and the ALDH1B1/ALDH2/METTL7A metabolic genes are secondary. Coordinated with M58 (focal adhesion) and M103 (matrix receptors) in the neighborhood, reinforcing an adhesion-complex assembly label rather than a metabolic one.
Genes
ALDH1B1, ALDH2, DST, FERMT2, ITGA5, KLHL42, METTL7A, NFIX, NPTN, PRKACB, RAB23, RDX
Most correlated modules
- SMC focal adhesion · correlation 0.85
- Matrix-integrin interaction · correlation 0.85
- Collagen-Laminin Deposition · correlation 0.83
- Lysosomal Glycoprotein Catabolism · correlation 0.82
- Basement Membrane Matrix · correlation 0.79
- SMC Contractile Signaling · correlation 0.79
- Notch-TGFbeta Signaling · correlation 0.78
- FOXF2 Mesenchymal Patterning · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.