Ubiquitin Signaling Response
Gene co-expression module in Colonocytes
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include UBE2K (ubiquitin-conjugating enzyme), RAD23B (ubiquitin receptor/proteasome delivery), PPP2R5A (PP2A phosphatase regulatory subunit), CRK and ABI1 (signaling adaptors), ARF6 (endosomal trafficking), DLG3 (scaffold), and PTBP3 (RNA-binding). The module is upregulated in UC inflammation. The combination of ubiquitin pathway components (UBE2K, RAD23B) with signaling adaptors and a phosphatase subunit suggests ubiquitin-mediated protein turnover and signal transduction, consistent with an inflammatory stress-response signaling program in colonocytes.
Genes
Most correlated modules
- Arp2/3 Actin Branching · correlation 0.92
- Integrin Adhesion Signaling · correlation 0.90
- Chromatin Regulatory Response · correlation 0.86
- ER-Golgi Trafficking · correlation 0.85
- mTOR Lysosomal Sensing · correlation 0.84
- Glycosylation & Membrane · correlation 0.83
- Hypoxic Oxidative Stress · correlation 0.83
- Colonocyte Detoxification · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.