UBE2K — Ubiquitin conjugating enzyme E2 K
UBE2K belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2K's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | RNA & Chromatin Regulation RNA processing | ATRX, DCP2, DIP2A, HNRNPLL, KDM5B, NCOR1, OGDH, RIOK3 +7 more | View in SCUBA |
| Gamma-delta T cells | DNA Damage Ubiquitin DNA/chromatin regulation | ACBD3, CDADC1, CTPS1, CWC25, FNIP1, ING3, KLHL18, RALGAPA1 +7 more | |
| Innate lymphoid cells | RNA Processing & Proteostasis RNA processing & translation | BZW1, CBX5, CSNK1A1, DDX21, EIF2S1, EIF3J, ENPP1, FNBP1 +11 more | View in SCUBA |
| Macrophages | Microtubule Organization Cytoskeletal | CAMSAP2, DESI2, FAF2, HERPUD2, KCMF1, LSM14A, MAPK6, NRDC +14 more | View in SCUBA |
About the gene
| Synonyms | HIP2, HYPG, UBC1 |
|---|---|
| Chromosome | 4: 39698109-39782792 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.