ER-Golgi Trafficking
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 44 genes have a known function matching the annotation |
Why this annotation
Hub genes RAB2A, TMED10, COPB2, LMAN2, RER1 are all canonical ER-to-Golgi vesicle trafficking components (COPI pathway). GDI2 regulates RAB GTPase recycling. RPN2 is an oligosaccharyltransferase subunit (N-glycosylation in ER). DNAJC3 is an ER-resident HSP40 chaperone. ATP6V0E1 is a V-ATPase subunit. LAPTM4A is a lysosomal membrane protein. ARPC1A and ARPC3 (Arp2/3 subunits) appear as peripheral members, likely reflecting the neighborhood co-expression with M10. The core program is clearly ER-Golgi vesicle trafficking and protein glycosylation. Moderate inflammation association, not as strongly UC-specific as neighbors.
Genes
Most correlated modules
- Hypoxic Oxidative Stress · correlation 0.94
- Unfolded Protein Response · correlation 0.91
- Arp2/3 Actin Branching · correlation 0.88
- Proteasome Activity · correlation 0.87
- Integrin Adhesion Signaling · correlation 0.86
- Ubiquitin Signaling Response · correlation 0.85
- Chromatin Regulatory Response · correlation 0.85
- ER Protein Processing · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.