Complex IV Assembly
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes are HIGD2A (HIG domain-containing protein 2A, Complex IV assembly factor), CMC1 (cytochrome c maturation/Complex IV assembly), SMDT1 (single-pass membrane protein with aspartate-rich tail 1, mitochondrial calcium uniporter regulator/EMRE), TMEM256 (mitochondrial inner membrane protein), TMEM14C (mitochondrial heme transport, required for heme biosynthesis and hemoglobin/cytochrome assembly), PTRHD1 (peptidyl-tRNA hydrolase domain containing 1, mitochondrial), CAMTA1 (calmodulin-binding transcription activator), IGBP1 (immunoglobulin-binding protein 1, PP2A regulator). The dominant theme is mitochondrial Complex IV assembly and mitochondrial inner membrane function. Strongly decreased in both UC and CD inflammation and restored with treatment. Neighbor context (M24, M54 are OxPhos modules) strongly supports mitochondrial identity.
Genes
Most correlated modules
- Proteasome Activity · correlation 0.95
- Oxidative Phosphorylation · correlation 0.94
- RNA Processing Translation · correlation 0.92
- Oxidative Phosphorylation · correlation 0.91
- Proteasome Assembly · correlation 0.90
- Cell Cycle Machinery · correlation 0.90
- ER Protein Processing · correlation 0.86
- RNA-binding & Splicing · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.