Oxidative Phosphorylation
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 19 of 37 genes have a known function matching the annotation |
Why this annotation
Hub genes are NDUF subunits (Complex I: NDUFAB1, NDUFA8, NDUFA12, NDUFB2, NDUFB5, NDUFA6, NDUFA4, NDUFC2, NDUFC1), UQCR subunits (Complex III: UQCR10, UQCRB, UQCRH), COX subunits (Complex IV: COX7C, COX6C, COX4I1), ATP5 subunits (Complex V: ATP5MF, ATP5PD), MDH2 (TCA cycle), MPC2 (mitochondrial pyruvate carrier), and EIF3K. All core membership. Strongly enriched in crypt colonocytes. Decreased in CD inflammation and restored with CD treatment, consistent with loss of normal colonocyte oxidative metabolism during active disease. Neighbor modules M7, M54, M23 all share mitochondrial/OxPhos themes, confirming this neighborhood represents colonocyte mitochondrial homeostasis.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.95
- RNA Processing Translation · correlation 0.95
- Mitochondrial Ribosome · correlation 0.94
- Complex IV Assembly · correlation 0.94
- Oxidative Phosphorylation · correlation 0.93
- Proteasome Activity · correlation 0.93
- Cell Cycle Machinery · correlation 0.92
- Mitochondrial Translation · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.