BMP-ID Progenitor
Gene co-expression module in Colonocytes
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes ID3 and ID2 are inhibitor of differentiation proteins, canonical BMP signaling targets that mark crypt base colonocytes and maintain progenitor identity by inhibiting differentiation-promoting bHLH transcription factors. FKBP4 is an HSP90 co-chaperone involved in steroid receptor and BMP receptor signaling. ZNF703 is a transcription factor. TCEAL9 is a transcription elongation factor. FABP5 is a fatty acid binding protein and Wnt/BMP target. CCDC112 and NUBPL are less characterized. The module is strongly suppressed in inflammation and restored in UC remission, consistent with loss of normal crypt progenitor identity during IBD. The ID2/ID3 BMP signaling axis is the defining feature.
Genes
Most correlated modules
- Mitochondrial Translation · correlation 0.91
- Mitochondrial Biogenesis · correlation 0.90
- Chaperone Proteostasis · correlation 0.87
- Colonocyte HOX Identity · correlation 0.87
- DNA Repair Housekeeping · correlation 0.86
- Colonocyte Differentiation · correlation 0.84
- Splicing Regulation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.