Splicing Regulation
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes SFPQ (splicing factor proline/glutamine-rich, also involved in transcription), SRSF2 (SR splicing factor), BCLAF1 (splicing and apoptosis regulator), CDC5L (Prp19 spliceosome complex), RSRC2 (splicing-related), CCNK (Cyclin K, obligate partner of CDK12 from neighboring M108), UBAP2 (ubiquitin-associated), USP16 (deubiquitinase), PABPC1 (poly-A binding, mRNA stability), TGIF1 (transcriptional repressor). The CCNK-CDK12 axis connecting M90 to M108 is a strong topological signal. Core coherence and uniform expression support a constitutive splicing/transcription regulatory program.
Genes
Most correlated modules
- SWI-SNF DNA Repair · correlation 0.92
- Ribosome Biogenesis · correlation 0.92
- Chromatin Transcriptional Control · correlation 0.90
- Chromatin-Coupled Splicing · correlation 0.88
- Pre-mRNA Splicing · correlation 0.88
- Chaperone Proteostasis · correlation 0.88
- Ribosome Biogenesis · correlation 0.87
- SUMOylation Chromatin · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.