Chaperone Proteostasis
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub genes include HSPD1 (HSP60, mitochondrial chaperonin), HSPE1 (HSP10, mitochondrial co-chaperonin), HSP90AB1 (cytosolic HSP90), AHSA1 (HSP90 ATPase activator), TIMM13 (mitochondrial inner membrane translocase), PPIA (cyclophilin A, chaperone/foldase). These form a chaperone-dominated core. SRRM1, SRSF3, HNRNPAB are splicing factors; EIF5B and EIF3J are translation initiation factors; YBX3 is an RNA-binding/translational regulator. As a neighbor to M103 and M53, this module bridges mitochondrial protein folding with general translation. The dominant program is proteostasis/chaperone activity in crypt colonocytes, with the mitochondrial chaperones (HSPD1/HSPE1) being the strongest hub genes.
Genes
Most correlated modules
- SWI-SNF DNA Repair · correlation 0.93
- Ribosome Biogenesis · correlation 0.92
- DNA Repair Housekeeping · correlation 0.91
- SUMOylation Chromatin · correlation 0.91
- Mitochondrial Ribosome · correlation 0.91
- CCT Chaperonin Folding · correlation 0.90
- snRNP Splicing · correlation 0.90
- Mitochondrial Translation · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.