snRNP Splicing
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 30 genes have a known function matching the annotation |
Why this annotation
The module is dominated by core spliceosomal Sm proteins (SNRPF, SNRPD1, SNRPE, SNRPD2) and LSm proteins (LSM2, LSM7, SNU13) that form the snRNP core essential for pre-mRNA splicing. Additional members include RANBP1 (RAN-dependent nuclear transport of snRNPs), NHP2 (H/ACA snoRNP for rRNA/snRNA modification), NPM1 (nucleolar chaperone), PRMT1 (arginine methylation of Sm proteins), BANF1 (nuclear envelope/chromatin), MRPL11/MRPL3 (mitoribosome), and NME1 (nucleotide supply). The strong crypt_colono enrichment and loss during inflammation reflect high splicing demand in proliferating crypt cells. The Sm/LSm protein dominance unambiguously identifies this as an mRNA splicing module.
Genes
Most correlated modules
- eIF3 Translation Initiation · correlation 0.99
- Cell Cycle Machinery · correlation 0.97
- RNA Processing Translation · correlation 0.96
- Mitochondrial Translation · correlation 0.96
- CCT Chaperonin Folding · correlation 0.96
- SUMOylation Chromatin · correlation 0.96
- Ribosome Biogenesis · correlation 0.95
- Ribosome Biogenesis · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.