eIF3 Translation Initiation
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 32 genes have a known function matching the annotation |
Why this annotation
Three eIF3 subunits (EIF3E, EIF3F, EIF3L) are the top hubs, with NACA (nascent polypeptide-associated complex alpha) and EEF1B2 (translation elongation factor) reinforcing a translation initiation/elongation program. CCT2 (chaperonin subunit) and PFDN5 (prefoldin) support co-translational folding. Mitochondrial components (TOMM7, TOMM20 import machinery; ATP5MC2 ATP synthase; TFAM mitochondrial transcription factor; SLC25A6 ADP/ATP carrier) reflect the high mitochondrial biogenesis in proliferating crypt cells. SF3A3 (splicing), APEX1 (DNA repair/redox), SERBP1 (RNA binding), CLNS1A, NSA2 (ribosome biogenesis) are peripheral. The eIF3 complex dominance identifies this as a translation initiation module with mitochondrial co-regulation.
Genes
Most correlated modules
- snRNP Splicing · correlation 0.99
- RNA Processing Translation · correlation 0.96
- Cell Cycle Machinery · correlation 0.96
- Ribosome Biogenesis · correlation 0.95
- Mitochondrial Translation · correlation 0.95
- CCT Chaperonin Folding · correlation 0.95
- SUMOylation Chromatin · correlation 0.95
- Ribosome Biogenesis · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.