Enterocyte lipid trafficking
Gene co-expression module in Enterocytes
| Category | Lipid metabolism |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Lipid handling and vesicular trafficking in absorptive enterocytes. SAR1B handles COPII export of chylomicrons, LPCAT3 drives phospholipid remodeling for lipid absorption, and UGCG makes glucosylceramide. CYP2J2 metabolizes epoxyeicosanoids, while RAB17 and TGOLN2 mediate apical/Golgi trafficking. This fits the neighboring apolipoprotein module M56.
Genes
CYP2J2, DYRK2, LPCAT3, MSRA, RAB17, RHOU, SAR1B, TGOLN2, UGCG
Most correlated modules
- Enterocyte fatty-acid catabolism · correlation 0.90
- Amino acid absorption · correlation 0.90
- Long-gene transcript bias · correlation 0.88
- Villus-tip enterocyte transport · correlation 0.86
- Amino acid absorption · correlation 0.86
- Mature enterocyte differentiation · correlation 0.85
- Chylomicron apolipoprotein assembly · correlation 0.84
- Mature colonocyte brush-border · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.