Enterocyte fatty-acid catabolism
Gene co-expression module in Enterocytes
| Category | Lipid metabolism |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
ACSL5 (fatty-acid activation) and ACOX1 (peroxisomal beta-oxidation) point to fatty-acid catabolism. OGDH (TCA cycle), CYP3A5 (xenobiotic metabolism) and GDA (guanine deamination) add broader metabolic activity. MUC3A marks the enterocyte glycocalyx and MIA2 lipoprotein export. This looks like a mature enterocyte metabolic/detoxification program sitting next to the M94 lipid-absorption module. RIOK3 is the hub but has no direct link to this program.
Genes
ACOX1, ACSL5, CYP3A5, GDA, MIA2, MUC3A, OGDH, RIOK3
Most correlated modules
- Amino acid absorption · correlation 0.92
- Brush-border enterocyte · correlation 0.90
- Enterocyte lipid trafficking · correlation 0.90
- Surface colonocyte lipid-droplet · correlation 0.89
- Epithelial junction polarity · correlation 0.87
- Chylomicron lipid absorption · correlation 0.87
- ER-autophagy homeostasis · correlation 0.86
- Apical Na+/H+ transport · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.