Epithelial junction polarity
Gene co-expression module in Enterocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
CXADR and MARVELD3 are tight junction components, and FRMD3 and PTPRD point to membrane-cytoskeleton adhesion. NEDD9 and SPAG9 are adhesion/signaling scaffolds, and RAB6A and KIF3B mediate polarized trafficking. Together these indicate an epithelial junction/polarity program. SLC52A1 (riboflavin) and SLC41A2 (Mg) are minor transport members. The module is generic, so confidence is moderate.
Genes
CXADR, FRMD3, IL13RA1, KIF3B, MARVELD3, NEDD9, PTPRD, RAB6A, SLC41A2, SLC52A1, SPAG9, SUSD6, TFG, ZER1
Most correlated modules
- Brush-border enterocyte · correlation 0.91
- Amino acid absorption · correlation 0.89
- Surface colonocyte lipid-droplet · correlation 0.89
- Endocytic nutrient uptake · correlation 0.88
- Enterocyte fatty-acid catabolism · correlation 0.87
- Junctional Hippo/TGF-beta signaling · correlation 0.87
- ER-autophagy homeostasis · correlation 0.85
- Mature enterocyte differentiation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.