ER-autophagy homeostasis
Gene co-expression module in Enterocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
RB1CC1 (FIP200) is an autophagy initiator, CTSD is a lysosomal protease, and REEP3 and AQP11 are ER membrane-shaping/ER genes. SMPDL3A and MFSD2A reflect lipid transport and handling. SPINT1 and PLOD2 are epithelial processing genes. Together this suggests a mild ER/autophagy-lysosome homeostasis program in differentiated cells.
Genes
AQP11, CCSER2, CTSD, MFSD2A, PLOD2, RB1CC1, REEP3, RESF1, SMPDL3A, SPINT1
Most correlated modules
- Amino acid absorption · correlation 0.91
- Endocytic nutrient uptake · correlation 0.89
- Surface colonocyte lipid-droplet · correlation 0.88
- Brush-border enterocyte · correlation 0.88
- Brush border lipid handling · correlation 0.88
- Chylomicron apolipoprotein assembly · correlation 0.87
- Enterocyte fatty-acid catabolism · correlation 0.86
- Epithelial junction polarity · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.