Endocytic nutrient uptake
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
LRP1 and DAB2 are endocytic receptor/adaptor genes, and SLC6A8, SLC43A2 and CDA handle nutrient uptake and metabolism. EGLN3 is hypoxia-responsive, and CREB3L2 drives secretory capacity. The best fit is receptor-mediated endocytosis with nutrient uptake, but the module is small and mixed.
Genes
CDA, CREB3L2, DAB2, DNAH7, EGLN3, LRP1, SLC43A2, SLC6A8
Most correlated modules
- Brush border lipid handling · correlation 0.90
- Amino acid absorption · correlation 0.90
- ER-autophagy homeostasis · correlation 0.89
- Epithelial junction polarity · correlation 0.88
- Surface colonocyte lipid-droplet · correlation 0.87
- Chylomicron apolipoprotein assembly · correlation 0.87
- Crypt-top colonocyte · correlation 0.85
- Mature enterocyte differentiation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.